Subject(s)
COVID-19/complications , Genital Diseases, Female/virology , Lip Diseases/virology , Ulcer/virology , Adult , COVID-19 Testing , Diagnosis, Differential , Female , Genital Diseases, Female/drug therapy , Glucocorticoids/therapeutic use , Humans , Lip Diseases/drug therapy , Prednisone/therapeutic use , SARS-CoV-2 , Ulcer/drug therapyABSTRACT
SJS is a rare mucocutaneous syndrome characterized by skin and mucous detachment. The main etiological factors are drugs and infections; sometimes the cause remains unknown. In the prodromal phase we observed non-specific symptoms, followed by mucocutaneous manifestation. Due to risk of complications and mortality a multidisciplinary approach is needed. We present a case of a girl with an atypical presentation of SJS related to Enterovirus.
Subject(s)
Enterovirus Infections/diagnosis , Stevens-Johnson Syndrome/virology , Adolescent , Conjunctivitis/virology , Edema/virology , Female , Humans , Lip Diseases/virology , Rhinitis/virologySubject(s)
Acyclovir/therapeutic use , Anti-Infective Agents, Local/therapeutic use , Antiviral Agents/therapeutic use , Fusidic Acid/therapeutic use , Herpes Simplex/diagnosis , Lip Diseases/diagnosis , Female , Herpes Simplex/drug therapy , Herpes Simplex/pathology , Herpes Simplex/virology , Humans , Lip Diseases/drug therapy , Lip Diseases/pathology , Lip Diseases/virology , Middle Aged , Skin Cream/therapeutic useABSTRACT
Herpes Labialis results from reactivation of latent herpes simplex virus (HSV-1 or HSV-2) harbored in the trigeminal ganglion during times of psychological stress, cutaneous injury or photo exposure. Following reactivation, the virus is anterogradely transported through axonal termini to the skin where the virus is released and replicates causing a clinical outbreak. Botulinum neurotoxin A (BoNTA) is known to inhibit presynaptic neuropeptide and neurotransmitter release. Whether it has the capacity to interfere with viral shedding and delivery into the skin remains unclear. We were interested in determining whether BoNTA could serve as a potential therapeutic or prophylactic treatment approach for frequent and severe HSV recurrences. We describe a clinical case report in which a patient successfully maintained a sustained absence of HSV outbreaks in regions where BoNTA was intradermally administered. BoNTA may offer a novel therapeutic approach for preventing recurrent HSV disease. J Drugs Dermatol. 2018;17(10):1127-1129.
Subject(s)
Botulinum Toxins, Type A/therapeutic use , Herpes Labialis/drug therapy , Herpesvirus 1, Human , Lip Diseases/drug therapy , Neurotoxins/therapeutic use , Adult , Botulinum Toxins, Type A/administration & dosage , Female , Herpes Labialis/pathology , Herpes Labialis/virology , Humans , Injections, Intradermal , Lip Diseases/pathology , Lip Diseases/virology , Neurotoxins/administration & dosage , Recurrence , Treatment OutcomeABSTRACT
BACKGROUND: Since the introduction of highly active antiretroviral therapy (HAART), an increase in the frequency of human papillomavirus-associated oral lesions (HPV-OL) has been observed. Thus, the aim of this study was to determine the prevalence and factors associated with HPV-OL in Mexican HIV-infected patients, as well as its genotyping, in the HAART era. METHODS: In a cross-sectional study developed at an HIV/AIDS referral center in Mexico City, HIV-infected patients were consecutively included from 2004 to 2011. An oral exam was performed; lymphocyte CD4(+) count, HIV-viral load, CDC-stage, and HAART use were recorded. HPV-OL samples were taken for routine histopathological analysis (H-E) and HPV-DNA amplification/sequencing. Logistic regression models were performed and the interactions tested using the STATA software. RESULTS: Among 787 HIV patients, 55 (6.9%) showed HPV-OL. HPV-OLs were independently associated with age (≥40 years) and with a longer time of HAART use (≥12 months). The most frequent lesion was squamous cell papilloma in 22 (40%) cases, followed by multifocal epithelial hyperplasia in 15 (27.3%) cases. Labial mucosa was the most common site involved (56.4%). Of the sequences obtained, 65.4% corresponded to low risk and 11.5% to high risk. Mixed high- and low-risk infection were identified in 7.7% of the cases. CONCLUSIONS: Human papillomavirus-associated oral lesions were associated with older age and longer HAART use. All lesions were benign in nature and most of the HPV sequences corresponded to low-risk types. The rise of HPV-OLs in HIV patients on HAART may be related with the longer life expectancy of individuals with an impaired immune system rather than a direct effect of HAART.
Subject(s)
Alphapapillomavirus/physiology , Antiretroviral Therapy, Highly Active , HIV Infections/drug therapy , Mouth Diseases/virology , Papillomavirus Infections/epidemiology , Acquired Immunodeficiency Syndrome/drug therapy , Adult , Age Factors , Alphapapillomavirus/classification , Alphapapillomavirus/genetics , Antiretroviral Therapy, Highly Active/statistics & numerical data , CD4 Lymphocyte Count , Cross-Sectional Studies , DNA, Viral/analysis , Female , Focal Epithelial Hyperplasia/epidemiology , Focal Epithelial Hyperplasia/virology , HIV/isolation & purification , Humans , Lip Diseases/epidemiology , Lip Diseases/virology , Male , Mexico/epidemiology , Mouth Diseases/epidemiology , Mouth Neoplasms/epidemiology , Mouth Neoplasms/virology , Papilloma/epidemiology , Papilloma/virology , Sequence Analysis, DNA , Viral LoadABSTRACT
Orf virus is the etiological agent of contagious ecthyma, a severe exanthematic disease that affects small ruminants. Orf virus is zoonosis that is associated with occupational contact with infected animals in human disease. Clinically, contagious ecthyma is characterized by the appearance of vesicles, pustules, ulcers, and papillomatous proliferative lesions on the skin of the lips and nostrils. Here we describe a case of lethal cutaneous multifocal Orf virus infection in goats in the Amazon region of Brazil. Exanthematic lesions were collected and epidemiological and clinical data were obtained. Orf virus was detected using PCR amplification of the whole B2L, VIR, and VEGF open reading frame. Phylogenetic analysis revealed that this virus clustered together with the Orf virus samples isolated during classical contagious ecthyma. The present work is the first to report a severe proliferative Orf virus case in South America.
Subject(s)
Goat Diseases/epidemiology , Goats/virology , Orf virus/isolation & purification , Orf virus/pathogenicity , Skin Diseases, Infectious/veterinary , Amino Acid Sequence , Animals , Brazil/epidemiology , Ecthyma, Contagious/epidemiology , Ecthyma, Contagious/pathology , Ecthyma, Contagious/virology , Genes, Viral , Goat Diseases/pathology , Goat Diseases/virology , Lip Diseases/epidemiology , Lip Diseases/pathology , Lip Diseases/veterinary , Lip Diseases/virology , Molecular Sequence Data , Orf virus/classification , Orf virus/genetics , Phylogeny , Sequence Alignment , Skin Diseases, Infectious/epidemiology , Skin Diseases, Infectious/virologyABSTRACT
Focal epithelial hyperplasia, or Heck's disease, is a relatively rare virus-induced benign disease. To the best of the authors' knowledge it has not been reported in an ethnic Chinese population. The authors report two cases of focal epithelial hyperplasia (FEH) in Chinese patients, which were clinically and histologically in accord with FEH. In particular, the lesions in one case were located on the gingival mucosa, which is rarely affected by FEH. DNA extracted from paraffin-embedded specimens from the two patients was tested for the presence of human papilloma virus followed by speciï¬c polymerase chain reaction testing for 16, 18, 13, and 32 subtypes in order to conï¬rm the clinical diagnosis.
Subject(s)
Alphapapillomavirus/isolation & purification , Focal Epithelial Hyperplasia/virology , Papillomavirus Infections/diagnosis , Adult , Alphapapillomavirus/classification , Child , China , Female , Focal Epithelial Hyperplasia/pathology , Gingival Diseases/pathology , Gingival Diseases/virology , Humans , Lip Diseases/pathology , Lip Diseases/virology , Mouth Mucosa/pathology , Mouth Mucosa/virology , Papillomavirus Infections/pathologyABSTRACT
Focal epithelial hyperplasia (FEH), or Heck's disease, is a benign proliferative viral infection of the oral mucosa that is related to Human Papil-lomavirus (HPV), mainly subtypes 13 and 32. Although this condition is known to exist in numerous populations and ethnic groups, the reported cases among Caucasians are relatively rare. It presents as asymptomatic papules or nodules on the oral mucosa, gingiva, tongue, and lips. Histopathologically, it is characterized by parakeratosis, epithelial hyperplasia, focal acanthosis, fusion, and horizontal outgrowth of epithelial ridges and the cells named mitozoids. The purpose of this case report was to present 3 cases of focal epithelial hyperplasia in a pediatric age group. Histopathological and clinical features of cases are discussed and DNA sequencing analysis is reported in which HPV 13, HPV 32, and HPV 11 genomes are detected.
Subject(s)
Alphapapillomavirus/classification , Focal Epithelial Hyperplasia/virology , Papillomavirus Infections/diagnosis , Sequence Analysis, DNA/methods , Adolescent , Alphapapillomavirus/genetics , Child , Female , Focal Epithelial Hyperplasia/pathology , Genome, Viral/genetics , Genotype , Human papillomavirus 11/isolation & purification , Humans , Lip Diseases/virology , Male , Mouth Mucosa/virology , Papillomavirus Infections/pathologyABSTRACT
Hand-foot-mouth disease is a common childhood viral infection. Generally, small vesicles and erosions occur on the hands, feet and oral mucosa. We report an unusual case of this disease that occurred in an immunocompent adult and resulted in severe erosion on the lips and mucous membranes.
Subject(s)
Hand, Foot and Mouth Disease/pathology , Lip Diseases/pathology , Mouth Mucosa/pathology , Enterovirus , Fluid Therapy/methods , Hand, Foot and Mouth Disease/therapy , Hand, Foot and Mouth Disease/virology , Humans , Immunocompetence , Lip Diseases/therapy , Lip Diseases/virology , Male , Mouth Mucosa/virology , Severity of Illness Index , Treatment Outcome , Young AdultSubject(s)
Focal Epithelial Hyperplasia/diagnosis , Lip Diseases/diagnosis , Papillomavirus Infections/diagnosis , Alphapapillomavirus/classification , Alphapapillomavirus/genetics , Alphapapillomavirus/isolation & purification , Chagas Disease/complications , Focal Epithelial Hyperplasia/complications , Focal Epithelial Hyperplasia/virology , Genotype , Humans , Inclusion Bodies, Viral/ultrastructure , Lip Diseases/complications , Lip Diseases/virology , Male , Papillomavirus Infections/complications , Papillomavirus Infections/virology , Paraguay/ethnology , Young AdultABSTRACT
Erythema multiforme is an acute mucocutaneous disorder, characterized by varying degrees of blistering and ulceration. We report a case of recurrent herpes-associated erythema multiforme managed with prophylactic acyclovir. An 11-year-old boy had lesions in the oral cavity and lips, which had been diagnosed as erythema multiforme minor. Four months later, the patient had desquamative gingivitis with erythematous lesions and necrotic areas in the skin. This episode was not related to drug intake, which suggests that the erythema multiforme was a result of herpetic infection. This hypothesis was supported by positive serology for herpes simplex virus. Five months later, the patient returned with new oral, skin and penis mucosal lesions. The diagnosis was confirmed as herpes simplex virus-associated erythema multiforme major. The episode was treated with acyclovir, and acyclovir was used prophylactically for 7 months to control the disease.
Subject(s)
Erythema Multiforme/virology , Lip Diseases/virology , Mouth Diseases/virology , Stomatitis, Herpetic/diagnosis , Acyclovir/therapeutic use , Antiviral Agents/therapeutic use , Child , Follow-Up Studies , Gingivitis/virology , Herpes Genitalis/diagnosis , Herpes Labialis/diagnosis , Humans , Male , Penile Diseases/virology , Recurrence , Simplexvirus/isolation & purificationSubject(s)
Lip Diseases/virology , Stomatitis, Herpetic/transmission , Child , Female , Humans , Lip Diseases/genetics , Male , Oral Ulcer/genetics , Oral Ulcer/virologyABSTRACT
Oral inverted ductal papillomas are rare benign tumours of minor salivary glands. A case that appeared in a middle-aged HIV+ woman simultaneous to two condyloma acuminata on the lips is described. The presence of human papilloma virus (HPV) 11 DNA was demonstrated in all the samples using polymerase chain reaction. HPV could play an important role in the aetiology and pathogenesis of these lesions in this patient.
Subject(s)
Condylomata Acuminata/pathology , HIV Seropositivity/pathology , Human papillomavirus 11/isolation & purification , Lip Diseases/pathology , Lip Neoplasms/pathology , Papilloma, Inverted/pathology , Salivary Gland Neoplasms/pathology , Salivary Glands, Minor/pathology , Adult , Condylomata Acuminata/virology , Epithelium/pathology , Female , Humans , Lip Diseases/virologyABSTRACT
Gingivostomatitis is the most common primary and symptomatic clinical manifestation of HSV-1 infection. Painful oral lesions appear as ulcerative erosions on the gingiva, palate, buccal mucosa, and tongue, leading to eating and drinking difficulties with an evolution between 10-14 days. This paper describes a case of a 19-month-old boy with severe painful Gingivostomatitis lesions. Low level laser therapy (LLLT) was used with an immediate outcome.
Subject(s)
Low-Level Light Therapy/methods , Stomatitis, Herpetic/radiotherapy , Follow-Up Studies , Humans , Infant , Lasers, Semiconductor/therapeutic use , Lip Diseases/radiotherapy , Lip Diseases/virology , Male , Oral Ulcer/radiotherapy , Oral Ulcer/virology , Tongue Diseases/radiotherapy , Tongue Diseases/virology , Treatment OutcomeSubject(s)
Focal Epithelial Hyperplasia/virology , Lip Diseases/virology , Neoplasms, Fibroepithelial/etiology , Tongue Neoplasms/etiology , Child , Diagnosis, Differential , Focal Epithelial Hyperplasia/pathology , Gammapapillomavirus , Humans , Lip Diseases/pathology , Male , Middle Aged , Neoplasms, Fibroepithelial/pathology , Tongue/injuries , Tongue Neoplasms/pathologySubject(s)
HIV Seropositivity/complications , Immunocompromised Host , Mouth Diseases/virology , Papillomaviridae/physiology , Warts/virology , AIDS-Related Opportunistic Infections/virology , Adult , Anti-HIV Agents/therapeutic use , Antiretroviral Therapy, Highly Active , Follow-Up Studies , Gingival Diseases/virology , Humans , Lip Diseases/virology , Male , Palate/virology , Recurrence , Treatment OutcomeSubject(s)
AIDS-Related Opportunistic Infections/virology , Anti-HIV Agents/therapeutic use , HIV Seropositivity/drug therapy , Mouth Diseases/virology , Papillomaviridae , Papillomavirus Infections/diagnosis , Tumor Virus Infections/diagnosis , Adult , Female , HIV Seropositivity/immunology , Humans , Lip Diseases/virology , Male , Middle Aged , Mouth Mucosa/virologyABSTRACT
A ten-month-old female was taken to the Children's Hospital of New York for evaluation of suspected child abuse. The child presented with a severe oral herpetic infection, tongue laceration, and multiple bite marks. Social services confirmed that a parent bit the child's tongue.